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If you add the process to the list in "On-Access Low-Risk Processes Policies" any files it opens will not be scanned (if you have configured the "On-Access Low-Risk Processes Policy" accordingly). Any files opened by other processes will be scanned accordingly to the settings in the "On-Access Default Processes Policy" (or "On-Access High-Risk Processes Policies" if you added the process there).
You will have to duplicate any folder exclusions to other process policies if you configured them to scan files. If you don't scan files in "On-Access Low-Risk Processes Policies" you will not need to add folder exclusions - the folders won't be scanned by these processes anyway.
In the "On-Access General Policies " you cannot configure any exclusions.