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You will need to add an exclusion or turn off that rule in access protection on that server.
There's also a whole load of exclusion you should add for exchange- KB51471
Kindly untick the block for "Prevent Mass Mailing Worms from Sending Mails" option for server.
Goto Menu - - ->Policy --->Policy catalog - - ->Select virus scan 8.x as product --->Access protection policy as category
Note : Also its important to exclude the files for exchange as said by Jane
Thanks Guys its working fine so far.