I am running windows 7 with Office 2007. Outlook is configured to launch at startup. I have noticed that McAfee intergration doesnt run. I think that Outlook may be launching to fast and McAfee hasnt loaded yet ?
If I close Outlook and re-open it McAfee Anti-Spam works
When Outlook is launched during startup, Can you verify Anti-Spam feature is available?
Steps to do that are as follows
In Outlook 2007 , click on Menu Tools==>Trust Center: This should display a window with various options on your left.
Click the second option "Add-ins", On your right it should display plugins currently loaded by Outlook. Can you verify whether "McAfee Addin" is listed under "Active Application Add-ins"
Also when you right click on a email, do you see a McAfee Anti-Spam menu ( At the bottom of displayed context menu )?