It's one of the features being considered for sure, but unfortunately, the whole "EPO world" is based on connectivity. All the concepts of central management, auditing, policy update etc revolve around being at least occasionaly connected.
What's your use case - do you really have no connectivity, ever? Not even occasional internet connectivity?
No connectivity in this particular environment. Will McAfee continue Endpoint Encryption separate from EPO (5.2.x and higher)?