Take a look at the agent log on the client and see if you can spot the communications issue. The agent log will be located in one of two places depending on the OS:
- C:\Documents and Settings\All Users\Application Data\McAfee\Common Framework\DB\agent_<machine name>.log
- C:\ProgramData\McAfee\Common Framework\DB\agent_<machine name>.log
Once you open the log go to the bottom and search upwards for "ASCI". You should be able to see where an agent-to-server communication session started. Then scroll down from that point and see what the error is. You can post the log if you like and someone here should be able to help you out.
Are the machines imaged machine? Is the machine communicating to the ePO server when you initiate ASCI (CmdAgent.exe /s) from the client machine? Are machine communicates when you reset the Agent GUID (KB#:KB56086)?