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Have you updated to the most recent Patch #7 yet, and if so, did it help.
Yes, McAfee uses more resources that Avast or any of the other free antivirus programs. . Then again, according to the license for Avast, the free version of Avast can not be used in a corporate situation.
Hope this helps.
We tested with Avast only to find out our resources problems.
Patch 7 is installed, but the performance seems to be bad like before.
Exclusions and what to scan is pretty important:
We only scan on writes.
All LOG files
C:\Windows\System32\CCM\ (SMS client)
C:\Documents and Settings\All Users\Application Data\McAfee\Common Framework\
Give that at try...
did you exclude these directories just on writes or read and writes and on what kind of Policies ?
there are many kind of policies General, High-Risk, Low-Risk etc.