Unfortunately it's a fact of life that no antivirus software is perfect. What one catches the other may miss and vice-versa. That's why there are so many other tools available.
The first insurance against this sort of thing is to be extra careful where you surf and what you click on or download. Browser early warning systems such as SiteAdvisor come in useful there.
In addition to your antivirus (only have one installed, more can be dangerous) it's always wise to have one or more anti-malware tools hand and updated, just in case.
There are some listed here under '3rd Party Tools': https://community.mcafee.com/docs/DOC-2168
Also it is vital to keep all aspects of your operating system up to date, even any parts you may not use, in particular your browsers, I.E. Firefox etc. and any associated add-ons. You don't state what OS and service pack this is but I would trust that you are up to date.
If a scanner misses something and you have a chance to report it to them then it's good to do that. McAfee has such a system too: http://www.mcafee.com/us/mcafee-labs/resources/how-to-submit-sample.aspx
It is rare for an infection to cause hardware failure and if it happens it's usually because something overheated. Are you sure that hard drive can't be saved by doing a disk check?
Start/Run and type in chkdsk /r (with the space) or chkdsk X: /r (with the spaces and X being whatever that drive letter is).
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This exploit comes in many different varieties, and you don't specify which one infected your machine. McAfee has a list of at least half a dozen, most of them known about and covered since at least as far back as 2009. It's possible that what you got was a new variant, not yet detected by McAfee.
It's not this piece of malware that necessarily does any damage, it's what else gets downloaded once it's installed.
Actually is not being picked up by McAfee. System Mechanics is picking it up on my computer.
File name being blocked at the moment is this:
USERS \APPDATA\ LOCAL\ MICROSOFT WINDOWS\ TEMPORARY INTERNET FILES\ LOW \CONTENT.IE5\ S8RP4V98\AC@BOTTOM3.HTM
This is only a generic name ( not the actual file downloaded )
The numbers after CONTENT.IE5 change each time it is blocked but everything else remains the same.
I have looked for and tried to erase these files. They are embedded pretty good in there.
If can isolate the actual files I will submit them to the labs so this doesn't occur to others!