Application Control might do the trick for you, managing per se is difficult (KB60776, McAfee Knowledgebase, https://community.mcafee.com/message/117735)
http://www.faronics.com/Faronics/Documents/DFEnt_McAfeeEPO.pdf, bloody old but still has some valuable bits and bops.
From the deep freeze website: "Deep Freeze 7 integrates seamlessly with our new Faronics Anti-Virus – Deep Freeze maintenance periods are no longer necessary. With the implementation of Storage Spaces in Faronics Core, anti-virus updates, such as signatures, engine or product updates, will occur and be retained even while your workstations are protected in a Frozen state!"
Not sure if all that can help, since I'm unsure on what deep freeze is doing, how it operates but I hope that can give some food for your thoughts.
Hey there - I know your posting is a few years old, but I'm wondering whether you ever figured out how to have Deep Freeze and an Anti-virus with updating DATs actually work? If you did happen to get this to work, would you mind letting me know what you did?
I have Deep Freeze standard on a laptop with ePO 4.6.