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Unfortunately you can't set a wildcard exception only actual files using the custom scan option, and the exception only works for a scheduled or a manual scan but not for the real-time scanner that works in the background.
If those files are unchanged and merely being stored it might be an idea to move them to a removable drive that you can disconnect.
Edit: We have been agitating to get this as a feature plus extend the exceptions to the real-time scanner, unsuccessfully so far.
It might be an idea to suggest it here: https://community.mcafee.com/community/home/ideas
It is already a part of the Enterprise product I believe.
Thank you for the reply.
The Real-time scanning should always be inclusive regardless. However, for other scans being able to exclude with wildcard would be a resource saver as a schedules/manual scan crippled my system with 100% CPU for over 48hrs and still had not finished. (That's a different issue I believe.)
Its a shame that the wildcard was removed in the 2012 version.
In a lot of cases these files are accessed regularly, so offlining them is an unavailable avenue.
Again thank you for your reply it was very helpful.
I'll bring this up on our conference call with McAfee today, meanwhile putting in a suggestion as I mentioned might be a good idea.
I wasn't aware that a wildcard setting was even possible in any previous consumer versions.
Across the board file and folder exceptions were possible back in VirusScan 7 days - even in real-time scanning but not wildcards as far as I recall.