We are having an issue with epo 4.6. The service will application service will run for sometime but you cannot login to the site after about 5 min. The server is a 2008 r2 running on vmware 4.1. We did make some changes to the system by modifying the registry java value to 1536 as recommended by McAfee. We also bumped the server to 6gb per their direction. Our ePO manages about 3500 end points.
Thanks in advance,
When application server service stopped, I will suggest you to look at Event viewer message and post the complete message with event id.