Moved this to VirusScan as a more appropriate spot for it.
You can only exclude items from the manual or scheduled scans but not the real-time scanner, yet. That's a feature we have been asking to be reintroduced.
Only items labelled as 'Possibly Unwanted Programs' (PUP's) can be trusted at the moment..
For now your only recourse is to submit a sample to the labs for analysis and hopeful exclusion from detection, read here: https://community.mcafee.com/thread/2016