Considering upgrading might be a good option of going forward. I guess support would ask you to do this anyway. MA 4.5 patch 3 (22.214.171.1242) has been out since June . You would need to post log files if the issue still persists after upgrading. Another question would be if you need repositories in the first place, there is a best practice guide which provides some guidelines.
Thanks very much for your reply.
I believe that to move forward with the problems we have we will have to get ALL systems upgraded to EPO 4.5 and patch 3.
Once again thanks very much for taking the time to reply.
You are welcome. As I said, check the best practice guide which should be found here:(https://kc.mcafee.com/resources/sites/MCAFEE/content/live/PRODUCT_DOCUMENTATION/ 23000/PD23051/en_US/epo_450_best_practices_guide_en-us.pdf.pdf
Page 26 onwards might help. Also, McAfee has introduced 'Lazy Caching' which might be something you want to look at. You would need 4.6 though for this to use.