I'm going to try some of these tips I learened from a platinum partner yesterday: In this case, adding premiere's .EXE to the low risk processes list should help a great deal perhaps.
1) a lot of administrators don't know about using high and low risk process exceptions in VSE. On-Access Low-Risk Processes Policies and On-Access High-Risk Processes Policies. To enable this, go to one or the other and radio button "Configure different scanning policies for high-risk, low-risk, and default processes."
If you (after testing yourself) instruct your clients who use mcafee to put your process executable name (e.g. myprogram.exe) in the low risk processes list (assuming it really is a low risk process, that your program doesn't handle a ton of malicious filetypes from the internet, and that you've done a good job vetting your software for vulnerabilities), that can improve performance tremendously as there will be a lot fewer checks done on all things that process does. If there are no entries in either high or low risk policy process exceptions, apparently all processes get the full checking treatment, which impacts performances. Apparently the mistake a lot of us make it to put processes in the On-Access Default Processes Policies list expecting the world to get better, when apparently the biggest performance boost will be had if a given process name gets on the On-Access Low-Risk Processes Policies list.
2) VSE 8.8 apparently has a lot of performance improvements over 8.7 due to the use of a scan cache. Customers on 8.8 are actively happy about the improvements.