Upgrade hit issues however that was due to the fact that the system had previously not been set up as best practise. The thing that got us out is that it is *critical* to exclude the DB folder and the main NSP app folder from VSE scanning (There may be a HIPS requirement aswell, however I dont see that listed above!).
With that sorted, and a rollback (ALWAYS take backups before upgrades!), the upgrade paths went smoothly when the documented upgrade paths were followed.
Its been a while since I touched this, and it may be a small amount of digging around in the documentation, but as said, the two critical things are: 1) VSE and HIPS exclusions and 2) Follow the supported upgrade paths documented in the release notes and upgrade guides. Also, I would recommend (if possible, I do not know system compatibility) moving to the latest v7.x version. Read through the upgrade guides for signs of caveats and gotchas, and for the most part you cant go wrong.
I hope this helps!
It'd been awhile since I last looked into upgrading, so after posting my inquiry I noticed that version 7 is out. I suppose, since my old system is on very old hardware, I'll just build a new VM and do a fresh install. I may even decide to start over with a new database, too.
I did see in the Installation Guide the exclusions needed for VSE. Thanks for the heads up!