Please look at KB#:KB69251.
Apologies, just found it
Unfortunately I run this patch and it says Error: Unable to find any qualifying McAfee Product(s). Plus I have too many clients that this is affecting to run this on, one by one. Poor show, this is one of the main reasons I use ePO apart from it's obvious function.
Do the affected machines have the exact problem mentioned in the KB? i.e. is the reg key missing? If so, exactly which version of VSE (including any patches) are they running?
No, the affected PC's do have the reg key with the correct settings to. We are using VSE 8.8, Agent 4.6 and ePO 4.6, in other words everything at latest version. Again today I noticed all clients in the same subnet as the ePO server seem ok (with 2 exceptions), just our remote links which it affect mainly.