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Starting with 6.7.2 HF2, TrustedSource lookups will use https: on TCP 443 by default. If your firewall doesn't allow that, Support can switch your Ironmail back to use port 53 or there is a patch you can download that will add a GUI option for you to do it yourself. Here's the URL for the patch: https://kc.mcafee.com/corporate/index?page=content&id=KB68684&remove=false
I'm in the middle of deploying new MEGs and upgraded one of my old IronMails running 6.7.1 HF7 to 6.7.2 HF5 so I could run a granular restore of the old config to the new hardware. That mostly went OK, although I missed a few spots that had specific IPs that needed to be changed on the new MEG. Also, the dashboard on the old box was pretty messed up after the upgrade, but that's purely cosmetic and I won't need to put up with it much longer anyway. Brand new hardware is shipping with 6.7.2 HF5, although HF6 should be generally available pretty soon if it isn't already. If you're going to go to 6.7.2, I'd suggest going all the way to HF5. Maybe someone with experience with the interim versions will express an opinion here.
I'm trying to sort out some pretty bad performance issues on the new hardware. Mail flow seems OK, but the web console and CLI are both way slow. 6.7.2 is running fine on the old hardware that was upgraded, although that's not very meaningful because there's almost no load on the old hardware either.
Hope this helps.