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I'm not sure that (at this stage) McAfee are talking about a 5300 series engine.
Instead that seem to be building on the 5200 series with the recent selective release of 5201 as part of it's Engine Component Update Technology Preview.
This new version only appears to be compatible with ePO 4.0, and GroupShield for Lotus Domino 7.0, GroupShield for Microsoft Exchange 7.0, PortalShield for Microsoft SharePoint 2.0, VirusScan Enterprise 8.5i.
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