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At first glance that looks like a network problem - 10060 is a timeout.
Have you introduced anything that can interfere with http traffic - changed config on a proxy, for example?
Can you pull successfully from the McAfee FTP site?
From the ePO server, can you download that file using a web browser?
Switching to FTP allowed the update to complete.
I'll start looking into why the HTTP failed.
Good news - at least you can pull successfully