I haven't done it myself yet, but this can be a good starting point:
I cannot predict if you will have problems installing ePO on an unsupported version of SQL (if I had to guess I'd say probably); however, support for SQL 2008 R2 will be introduced with ePO 4.5 patch 4 which should release in Q1 2011. You can reference the supported environments doc for ePO for this (KB51569):
McAfee support, I replied:
ven we have determined the ePO system if it can run on cluster but it is not necessary since ePO is a program manager and not a server per se, that is, if the PC fails the ePO'smanaged not fail to protect the stations.
Having said this, I enclose a PDF document with instructions for implementing the cluster method ePO Regarding the license, not an additional need for ePO and SQL only requires1 with good redundancy (RAID5) or want an additional , would then have to talk to the Microsoft sales department
try it now plays!,