You can created a Trusted Directory from the 'Application Control Policies' menu in ePO. A trusted directory will not be subject to Application Control's whitelist check.
Trusted directory will allow the execution of supported files from directory even if the files are not whitelisted. But it will not allow modification to the solidified files in the directory.
Solidcore future releases will have a feature to skip solidification of user desired directories. This way user can modify the files on unsolidified directory and adding the unsolidified directory as trusted will execution of the unsolidified files. But memory protection will still be active on the processes running from this directory.