This is overkill. It is not what AH's are designed for, and may cause issues on your site.
1000 nodes is a tiny environment based on what EPO can support. Instead, I believe you should be using SuperAgents to do what you're thinking of.
If it helps, I have a 10K node site, with only one EPO server and one AH. The AH is solely used for DMZ management of clients, and nothing else.
I agree with this completely: AHs are overkill, and a simpler distributed repository model would suit this environment much better, I feel.
Following McAfee specs an AH (so ePO also) can support up to 50.000 nodes depending on the hardware