Have you tried doing a forceuninstall/reinstall of the agent? I've seen this issue and it normally will not be resolved without forceuninstalling the agent. Sometimes it might take removing all mcafee products and deleting all related folders and registry entries as well. Reboot and reinstall fresh to see if that clears it up.
So far what we have done:
Completely uninstalled the McAfee Agent and re-installled
Verified site list is correct
Tested MA removal and install on other systems and every one worked without a problem
The machine in question is a DC and it if functioning just fine but simply will not communicate with the ePO server. There isn't anything special about this machine relating to network placement and we even created a specific pointer record to ensure there were no DNS issues.
the agent communiction ports arent already in use of the DC? have you run a port query?
No, ports havent changed. From what I understand, the system in question had been placed in an MA group with a firewall enabled. Since that time, they attempted to move it back into its proper MA group only to discover that there was no agent-server comm.
We have accessed the client UI and disabled HIPS and have since restored all functionality DC,DNS etc. to the server and it's working fine exept the Agent/ Server comm.
Since you have HIPS on it I'd also remove that completely and see if it has any impact on the issue.