Just on the server itself or is it managed by an epo server which sets AV policy and will probably overwrite anything you input?
to set it one the server just go into the vse console from the start menu ( or right clicking on the vse systray icon)
right click on on access scanner
all processes option fom left
add exclusion you want and also if you have any on demend scans enabled as taks ( these may show up further down the console) then you may want to add the exlusion there too.
for epo you find the machine and edit the policy but exactky how you do this depends on what version of epo you are using.
see this video tutorial for instructions on managing exclusions https://kc.mcafee.com/resources/sites/MCAFEE/content/live/TUTORIALS/30000/TU3005 3/en_US/corp_tutorial.htm
moved to VSE community....