If it's the 2009 version (square taskbar icon) double-click the icon to open SecurityCenter then click About in the lower right-hand corner to check the versions of each application.
If it's the 2010 version (shield-shaped icon) double-click as above then click Navigation at top right, then About at left to get the various versions.
Real-time protection showing off in Safe Mode would be normal as most processes don't load in that mode, including SecurityCenter
Follow the steps in this document first: http://community.mcafee.com/docs/DOC-1294
If that doesn't help then download, install and update, then run the FREE version of THIS software.
Let it remove everything it finds and reboot if asked to.
No anti-virus application is proof against everything out there, one has to be really careful.