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If you rename the ePO 4.5 server, you would need to regenerate the Apache SSL Server certificate refer to KB66620 for details. Assuming the Agent server communication keys from the older ePO 4.0 server are imported to your newer ePO 4.5 server, this may just work. But this not the regular upgrade path - so you may want to take a backup of your existing ePO 4.0 installation according to the Disaster recovery KB51438 before going further.
Thanks, I'll take a look at the KBs. Unfortunatly this is the only way to get the OS to a 64 bit version. I could format the old server and reinstall but as some of the ePO settings are not stored in the database I would still need to configure the new ePO version and without a comparison available I may miss something. Can I push new ePO agents out and replace the old ePO server cert with the new server cert? Or is it best to import the old certificates? I will be importing from AD to get the list of systems to manage. Thanks.