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v 4.0 is not supported on x64
You need to install v4.5
Corporate KnowledgeBase ID: KB52397
Product Statement: ePO compatibility with Windows 2008 Server
Supported with the release of ePO 4.0 Patch 3 (on 32-bit systems only). For the ePolicy Orchestrator 4.0 Patch 3 Release Notes, see KB53887.
* ePO 4.0 is not supported on 64-bit operating systems. The next full product release of ePO is scheduled to support 64-bit versions. Additionally, support for Microsoft Windows Server 2008 clustered environments is currently not planned for ePO 4.0. For more information, see KB65460.
* ePO 4.0 is not supported in the Windows Server 2008 Hyper-V virtual environment. Hyper-V is supported with ePO 4.5 only.
4.5 ePolicy Orchestrator supports the following 2008 environments:
* Windows Server 2008 Hyper-V
* Windows Server 2008 Standard, Enterprise, DataCenter (32-bit and 64-bit)
For further details, see PD21813
- McAfee ePolicy Orchestrator 4.5 Installation Guide
moving to ePO forum