Can you provide more details on what type of Distributed Repository it is , version info of ePO and Agent? Check if the Replication credentials specified have proper access to the share (if UNC).
Same issue here. SADR just stopped replicating.
I can telnet back to the ePo on ports 80 and 8443 and communication is fine, just wont update with the error that the SiteStat.xml cant be uploaded due to "Acess Denied".
Running agent 4.5 and ePo 4.0
McAfee Framework service is running - restarted service and machine.
Nothing jumping out in the logs either except an obscure reference to incrprop.xml.
You may want to check if KB67453 applies.
Oddly enough, the fix we had for this was to downgrade the agents on our SADR's back to 4.0 from 4.5.
I had re-installed the 4.5 agent a couple times on these machines, but no luck.
Downgraded to 4.0 and replication took off.
From the epo, those machines that could replicate successfully were accessible by http://<machinename>:8080
SADR's at the same site that could not be connected to were not.