I believe the migration from ePo's earlier version to the the latest version has corrupted the HIPS files. This KB article give syou the info about the same.
Have you installed the Patch1 for the ePO 4.5 yet or not ?
If not, I suggest you do that at the earliest.
thanks for the short reply. Currently i have installed the epo 4.5 w SP 1. So there is no need to reinstall the same. Any other hints regarding that issue?