Hi Mahesh, the only way should be using an SQL server instead of MSDE.
As stated, MSDE2000 has a hard-limit of 2Gb which cannot be increased.
Note: MSDE2005 doubles this to 4Gb, Full Sql is not limited in this way.
Please also note that ePO 3.6.1 is no longer supported by McAfee.
If you upgrade to the current (4.5) version you will also be migrating to MSDE2005.