Is your computer managed by ePolicy Orchestrator by any chance?
Have you tried changing any other settings in that section (reporting on or off) and do these changes stick at all?
I'm having the same issue just like zhan. I'm using ePO 4.5. However the ePO is having issues of late (McAfee Support trying to resolve this). My project development team is chasing me on this issue as their server need to use port 25 for email usage. How can I permanently unblock port 25 at the client end.
If you have excluded the process in ePO server then the same should be refiected on the clients. If that's not happening then probably there should be Agent to server communication issue. So please test by enabling/disabling any feature for testing on this machine to see if the latest policy is applied to confirm that no issues with communication.
Which version is VSE running on client?
If you have recently installed VSE or upgraded to latest version then have you installed the extension for the same VSE version in ePO?
Are you modifying the same version of VSE policy in ePO?