Mcafee products would be completely disabled in safe mode. Boot the computer in safe mode and if you open security center, you could find that all sections would be disabled in the security center User interface.
Apart from this if your file is been quarantined as a false positive , you could submit the file to McAfee labs by which they would be sending you a extra DAT, please follow the steps to submit the files.
http://service.mcafee.com/faqdocument.aspx?id=TS100095&lang=en_US&prior_tid=2&An swerID=16777216&turl==http%3A%2F%2Fkb.mcafee.com%2Finfocenter%2Findex%3Fpage%3Dc ontent%26id%3DTS100095%26actp%3Dsearch
As i mentioned in my first post safe mode does not disable macafee completely it still leaves something running, and ive just tried submitting the file through security centre and its telling me the file is to large and cannot be sent to macafee. And if i try and restore it, macafee just deletes it again straight away. and then says cannot be restored.
Sure,You could try uploading the file to Webimmune or sending a email to avertlabs as instructed in my previous post, and they would be responding to you. Hope this would help you to proceed further with your file.
To stop it deleting the file simply do 2 things. Turn off VirusScan and uncheck the Active Protection option.
Double-click the taskbar icon to open SecurityCenter
Click Advanced Menu (bottom)
Click Configure (left)
Click Computer & Files (top left)
You can disable VirusScan and tell it for how long over at the right.
If you click the Advanced button at the right you can then go to Active Protection on the left and uncheck it. Don't forget to click Apply and OK.
(If the detection was labelled "Artemis" then doing this alone will stop the detection, but note it reduces security).
You can then go to the Restore tab/Files and restore the item.
That should stop all detections until you tell it otherwise and enable you to forward the file to McAfee for checking.
Here are some guidelines regarding false detections: http://community.mcafee.com/message/6645#6645