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Neither an agent wakeup call nor the agent status monitor updates DAT files for VSE rather they instruct the agent to update its properties on the EPO server and download any new policies/tasks. If you wish to perform a DAT update via a wakeup call then you must define a client update task in EPO and set the task to "Run Immediately". Then the client will perform an update on its next agent-to-server communication (which you can force with a wakeup call).
Keep in mind that tasks set to "run immediately" will only run one time on the client machine and they will not run again unless the task has been changed somehow (simply opening the task and saving it is sufficient).
you can also remotely run 'C:\Program Files\McAfee\VirusScan Enterprise\mcupdate.exe' which will start the same process you see when running 'Update Now' locally - you can then monitor progress via remote log...