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* Disable any server tasks you currently have enabled
* Disable any security software running on the server (especially any AV product)
* Restart all 3 EPO services immediatly before launching the upgrade
Of course once the upgrade is complete you'll want to be sure and re-enable the server tasks and your security
Also if you have not already done so make sure you have the appropriate files backed up before attempting the upgrade just incase something goes wrong. KB51438 lists everything you should backup:
I'm also having this same issue:"Setup was unable to backup the existing EPO folder, D:\epo4. Please close any applications that might be accessing that folder". I've disabled server tasks, av software and rebooted. I ran Processmon during the attempted upgrade and saw a few "ACCESS DENIED" errors at about the same time as the setup failure.
Date & Time: 3/15/2010 1:06:48 PM
Event Class: File System
Result: ACCESS DENIED
FileName: D:\Backup of epo4
Any other suggestions?