It is a completely new product, there are no patches for it as of yet.
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To the point of "does MA 4.5 include fixes that came along in MA 4.0?" -- yes for the most part. Since 4.5 was developed in parallel to some of the patch releases, most were rolled forward and any that missed get swept up in the first 4.5 patch after the last 4.0 patch. Agent patches within a version are cumulative, by the way.