No it shouldn't be an issue. As I stated back then it shouldn't be necessary but I prefer to do it that way.
Thanks. This time this did not work on my desktop. I had to contact technical support after about 3 hrs of trying to remove using tool, checking for file remants etc. and after a long time with tech support (maybe around 2 hrs across 2 technicians at different levels) they recommended resetting my XP windows security to default (using MS Fixit tool) and then rerunning the removal tool. After this total protection installed ok. I should mention that I was removing Internet Security 2009 and installing Total Protection 2010. I remember having problems the last time I moved up on McAfee products (I think it was VirusScan Plus or something like that to Internet Security). At any rate 6 hs later I was ok. Approached laptop with trepidation but this worked ok (first removing old and then installing new) in just a few minutes--also XP Professional. Technician said this was a known problem with XP. I did however appreciate the willingness of the technician to work to solve the problem. Also before doing any removal/installing I was told to be sure windows is updated with any critical updates. It might be that 1 is available that day but not yet installed on the machine and could affect the installation.
I do notice that my system has slowed down some with total protection vs Internet Security. For a short while when I was working just with the Windows firewall it was nice to have a speedy system like in days of yore. These security programs do slow things down, But alas we do need them.
Well I'm glad that it finally is sorted out. The system may bog down a bit at first but should ease up when things get settled in. However, with XP I found things can easily slow it down. I finally gave up on XP when I got a new PC a few months ago.
How much installed memory (RAM) does your machine have?