Mcafee does not fix registry entries ie smae as a registry cleaner does it can fix entries a virus has added though. I myself feel registry cleaners can cause more harm than they fix. that said try the following
First try updating your dat files a new 1 that covers the malware/issue might be available. If that gives no joy then:---
Try scanning your PC in safe mode.i.e.
Tap F8 repeatedly while booting up. You'll get a boot screen with choices. Pick Safe Mode. Your PC will boot in a low resolution state as most processes wont be running.
Go to "My Computer" (XP) or "Computer" (Vista), right-click the hard drive and select "Scan" from the drop-down menu.
All you'll see is an extra taskbar icon which will show a progress report if you hover over it.
or if still no good
If things are still unstable or your want a second opinion then to be on the safe side scan with the free versions of these tools:
If malwarebytes was already installed and the virus could be protecting itself against it try this
In order to get Malwarebytes running, you'll need to rename the executable.. If Malwarebytes is already
installed, open the C:\Program Files\Malwarebytes Antimalware folder, then rename the "mbam.exe" file
to something else, like "gogetum.com", then double click directly on the file to open the program.
After updating the program, Run a full system scan using Malwarebytes
Update both programs them before running them and let them clean anything they find. If they quarantine
a file or fails to remove a file try to get a copy of it and send it to Mcafee using the virus submission path described here.