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Apologies if this sounds like an RTM reply - but the ePO 4.5 Product Guide can help you here.
1) See "Synchronising the system tree on a schedule", page 127
2) See "Configuring Agent Polices to use a distributed repository", page 187
3) I would guess that the throttle is set: see "Setting Thresholds of the rule", page 259
Number 4 on the other hand will require deeper investigation The first place to be looking is the agent_machinename.log and mcscript.log on the client machines.
Many thanks Joe I do deserve that
Have just had 2 days getting ePO up and not seeing the wood for the trees, now solved 1-3, 4 on the other down to problematic workstations methinks.