This could be the issue related to scanning of cookie files. This issue is documented in VirusScan Enterprise Patch 2 Readme.
Please go to the McAfee Service Portal HERE and click on the link for "Search The Knowledge Base". Search for article KB67130.
The issue can be resolved by either disabling the option to scan for cookies in the On Access Scan configuration, or upgrade to the 5400 engine which can be downloaded in SuperDAT form from HERE
Hope this helps, please let me know.
I downloaded engine 5400 for epo and pushed it out to the clients, and so far it seems like the error has disappeard
Thanks for your help.