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We suggest people use the free version of Malwarebytes when certain infections have invaded their machines.
Likewise people have used Spybot free with no problems as long as teatimer is not activated.
Basically as long as real-time protection isn't activated you should be OK. Stick to the basic free versions and you shgould be OK.
Recommended anti-spyware tools to use as a supplement to McAfee are listed at the top here: http://community.mcafee.com/showthread.php?t=136913