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XP SP3 I hope? You mention "on all our machines: - is this the home product you are asking about or MTP for Small Business? If the latter there is no support here as per: http://community.mcafee.com/showthread.php?t=217973
McAfee relies on an up to date and fully functioning Internet Explorer (set to default values under Tools/Internet Options/Security & Advanced tabs), regardless of whether or not you use it.
You should be using IE8 by now to be secure and one thing to try is go to Tools/Internet Options/Advanced and click Reset. Then click Apply and Ok and exit IE.
Reopen it and re-enable all the add-ons under Tools/manage Add-ons.
See if that helps.