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Have you tried going to that file location, right-clicking it and selecting "Scan" to see if it completes when asked to scan a single file? You may have to enable "View Hidden Files & Folders" in Windows Explorer Tools/Folder Options/View to actually see it.
Another thing to check is for hard disk errors.
If you are using XP go to Start/Run and type in cmd then click Enter.
If Vista got to Start and type cmd in the Start Search box immediately above. When cmd.exe appears in the list above that right-click it and select "Run as Administrator".
In the Command Prompt box type in chkdsk C: /r (with the spaces and alter C: to whatever drive letter is involved) and then hit the Enter key.
It will say that it cannot proceed as the volume is in use, proceed at next boot Y/N? Type Y and hit the Enter key.
Reboot and let the disk check run its course.
See if that helps.
Many thanks for your help last week. I did a chkdsk as I had already tried the individual manual scan on the file which didn't work. Following the running of chkdsk, which replaced a couple of files (one being the problem file) I have now successfully carried out a full scan on my PC.
Glad to help.