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Try to use the HTTP Settings > 'Keep alive' > 'Enable Comfort Page'.
!!! If you use this setting Uncheck 'Block Failed Items'. RTFM/KB.
Make sure SecurityShield runs Engine Version 5300 (NOT 4400).
Do you use VSE on the ISA Server? Yes, you HAVE to set some Exclusions in the On-Access Scan Properties!
C:\Program Files\Microsoft ISA Server
C:\Program Files\Microsoft SQL Server
C:\Program Files\Network Associates
Did you follow the Readme Setup for Patch 5?
If Patch 5 is installed on Windows 2003 Server
it might not create the TEMP folder within
SecurityShield’s BIN folder because the Network
Service does not have "Write" permission to this
folder. Please execute the following steps to
provide Network Service Write Permission.
4. Browse the SecurityShield installation folder
C:\Program files\Network Associates\McAfee SecurityShield\bin
5. Open the Properties page of SecurityShield’s BIN
folder by right clicking on the BIN folder and
6. Click Security Tab.
7. Click Add and type in "Network Service" and
8. Check "Full Control" checkbox in the Permissions
9. Repeat Steps 2-4 for the folder:
C:\Program Files\Common Files\Network Associates\Talkback\Data