VSE is installed locally on systems for local scanning and can be a stand-alone install or managed by epo. With MOVE multiplatform, scanning is done by an offload scan server on virtual machines. From the product guide for MOVE, here is a better description (PD26120 for the 3.6.1 version):
McAfee Management for Optimized Virtual Environments AntiVirus (McAfee® MOVE AntiVirus) is an
anti-virus solution for virtual environments. It removes the need to install an anti-virus application on
every virtual machine (VM), yet provides the protection and performance needed for your organization
Traditional security solutions for virtual machines need anti-virus applications running on every virtual
machine (VM) on a hypervisor, contributing to high disk CPU and memory usage. This reduces VM
density on each hypervisor.
McAfee MOVE AV solves this issue by offloading all on-access scanning to a dedicated VM that runs
McAfee® VirusScan® Enterprise. As a result, traditional anti-virus applications are not required on each
guest VM, improving performance and increasing VM density per hypervisor.
McAfee MOVE AV brings advanced malware protection to your virtualized environments, and integrates
real-time threat intelligence with security management across your physical and virtual infrastructure.
McAfee MOVE AV provides two deployment options: Agentless and Multi-Platform. Both deployment
options provide consistent protection, and are managed and reported by McAfee® ePolicy Orchestrator®