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We just enabled it a few days ago at the default "Very Low" setting in a network of aprox 750 clients after testing it in a small branch of about 10 clients. So far, we've seen no real change or instances of false positives. One condition to our environment is that we also have a web appliance that does 1st line spyware/av filtering.
"Very Low" will use the next days DATs, so you get the false positive one day earlier ;)
Here are the different levels explained
Disabled: Artemis Technology is turned off
Very Low: Equivalent to next days DATs. Get tomorrow's protection today. Recommended initial configuration
Low: Protection in addition to DATs.
Medium: Used when the risk of regular exposure to malware is greater than the risk of a false positive.
High: Recommended for deployment to systems or areas which are regulary infected.
Very High: Recommended for use in email and On-Demand Scans on non-operating system volumes.