I solved my own problem but McAfee doesn't have the issue very well documented. In my case everything except Microsoft Edge was working and it turned out disabling the Script as Updater (SAU) solved my issue.
Command: sadmin config set DisableDeviceGuardCompat=1
McAfee KB89466 vaguely discusses apps not functioning but it doesn't provide any specifics into the actual behavior you will encounter. It also provides the command that was referenced above.