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Found the solution in another thread:
The mcafee server service will fail to start, if IIS has already started before it. So basically, stop the IIS Admin service (and allow it to stop other processes that depend on it), start the Mcafee EPO server service, then start your IIS services again, and it should work fine :)
ePO 4.0 Known Issues - Other
- During normal operations you may receive an Apache error (ID 3299) noting the disabled use of AcceptEx. This is not an actual error, and should be regarded as informational.