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The McAfee AV Installer will attempt to remove the majority of mainstream commercial AV products prior to installing itself.
ePO allows you to import lists of systems from plain text files so provided that you can generate a suitable formatted list from your Symantec Console importing it the structure into ePO shouldn't be too tiresome.
Your main "problem area" I would guess will be replicating your current AV policy setup over onto the policy options available in the AV product but I guess that's the bit you'll need to spend some time on configuring and testing.
Have a good read of the available documentation and get some hands on tesing setup for ePO ASAP and get comfortable with the concepts it relies on. If you can try and get some training.
symantec also provide a full removal tool for problem installs, you may want to download this in advance