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ePO (McAfee) and WSUS (Microsoft) don't have anything in common. Every PC has to have McAfee agent to be able to communicate with your ePO server to update/download a new signatures/patches etc.
I'm not really sure whether you understand ePO and how all the things work (agent, repository, tasks, policies ...) since it's quite different approach than WSUS or SMS server. Did you have time to go through the docs? You need that knowledge to administer ePO and frankly, I think that ePO is much more complicated than WSUS.
Also you can have both the apps installed on a same server, not a problem at all.
I think you have WSUS (Windows Server Update Services) and SCCM (System Center Configuration Manager) confused.
WSUS is only a Windows update repository. You use this as a central facility to approve and store Windows updates.
SCCM is what lets you micro manage your PC's and do things such as deploy software.
So you have a couple options on deployment of your ePO agents. If you're running Active Directory you can use ePolicy to deploy the agents or you can deploy it with Group Policy in AD.
If you do not have AD (like me) you will need to use some other form of login scripts or manual installation.