CHECK YOUR ON ACCESS Exceptions and ESP things like:
**\test.exe mytest.exe switzerland.exe
Which was on VSE 8.8 "test.exe mytest.exe switzerland.exe" in one row and seemed to Exclude those seperate EXE.
In ENS 10.5.X we have seen 100% CPU Boost because of those
In ENS 10.5.1 we have seen Migrations FIALING (Second Module Threat Prevention) and doinf a Rollback to 10.2 and the again to 10.5.1 (This may be something you don't even see).
* Go through your ON ACCESS Exceptions ONCE under all THREE options (Low/HIGH/Standard).
* MAKE SURE ONE TIME you have the optione "Overwrite CLients Exclusion" once. If those are not valid it will stay forever. You can take the checkbox out after that.