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ePO 4.5 Using Microsoft's sites and services

Hello,

Has anyone been successful in using SADR replication to MS's Sites and Services scheme? We have a very large large company that has hundreds of dedicated sadr's around the world that all of our boxes communicate with. We would like to lower the traffic across the world by isolating which sites do what. Now this canbe done by creating a dedicated policy for each site, however its too many sites per sadr. Since we have Active Directory's Sites and Services, it would make since for our systems to follow the scheme. Any thoughts??